As of 1999, there had been 35 research projects conducted in Guatopo (Carlsen 1999), which shows lack of research interest when compared to other parks like El Ávila. Among the research, Edgard Yerena's stands out because of its importance and contents. He conducted a characterization and analysis of the park's natural resources, including a complete study of its geologic relief, climate, water, flora, and fauna. He included a zoning proposal in a management plan and elaborated the basis for a biological monitoring plan, focusing mostly on researching and monitoring flora and fauna resources (Yerena 1985).
Several studies focused on the park's biodiversity, including a study of the floristic composition of the evergreen rainforests by Argelia Silva, Gerardo Aymard, and Winfried Meier in 1993. In this research, they compared two forest parcels, one that was subjected to agricultural activities and the other that contained primary forest species (Silva and col. 1993).
Miguel Lentino, Alejandro Luy, and Mary Lou Goodwin elaborated Guatopo's birdlist, which includes 403 species (Lentino and col. 1993). The Ministry of Environment and Natural Resources conducted a wildlife and fish inventory in order to make a preliminary estimate of the environmental impact the Taguaza Dam construction would have on the aquatic and terrestrial fauna (De Sola and col. 1996). González-Sponga (1997) conducted another notable study, in which he discovered a new spider species called Schizomus yolandae.
There have also been several undergraduate thesis research studies conducted (for a bachelor's in biology), focusing on bird communities. Anne Marie Herrera conducted one study on insectivores and Antonio Briceño studied hummingbirds (Novo and col. 1997).
More recently, Edgard Yerena, Carlos Guariguata, and Jorge Padrón conducted a preliminary study for a proposal to increase the park. They recommended including parts of Bachiller Ridge (towards the east) and Cerro Golfo Triste (towards the west) within Guatopo (Yerena and col. 2000). Three rivers' headwaters begin in Cerro Golfo Triste (Cura, Tunapuey, and Zuata) and they flow towards the Camatagua Dam, which supplies the most water to Caracas, as well as Tarma, Caisito, and Súcuta Rivers, which are part of the Tuy River basin (Nehlin 2004).
There are no current research projects in the zone, except for HIDROCAPITAL's periodic monitoring of the water levels in the dams. However, the Fundación Instituto Botánico de Venezuela and Universidad Simón Bolívar are interested in conducting short-term research projects in the future.